Education

1997 - 2003    Ph.D., Experimental Pathology

University of Texas Medical Branch

Galveston, Texas, United States

1991 - 1996    B.M., Clinical Medicine

Beijing Medical University (Peking University Health Science Center), Beijing, China

Academic Experience

2015 – present  Professor    School of Medicine, Tsinghua University

2009 – 2015      Tenure-track Associate Professor    School of Medicine, Tsinghua University

2003 – 2009      Postdoctoral Fellow    Laboratory of Immunology, NIAID/NIH, United States

1997 – 2003      Research Assistant    Department of Pathology University of Texas Medical Branch Galveston, Texas, United States

Overview of Academic Research

Hai Qi’ research focuses on humoral immune regulation and germinal center biology. His work has made important contributions to our understanding of molecular mechanisms underlying T-B interactions, follicular helper T-cell development and function, and germinal center positive selection. His group has also made important advances in mechanistic understanding of how sexual dimorphism is orchestrated in B-cell immunity and how brain can directly control antibody responses. With over 70 scientific publications, including publications in Nature, Science, Immunity etc.

Major Honor and Awards

2019       Outstanding Research of Higher Education Institutions Award, Chinese Ministry of Education

2018       AAI-BD Investigator Award

2017       Shulan Medical Award

2017       HHMI International Research Scholar

2016       Wu Jieping-Paul Janssen Medical & Pharmaceutical Award

2015       Tan Jiazhen Life Science Innovation Award

 

Representative Research Achievements 

1.Xin Liu*, Jiacheng Yao*, Yongshan Zhao, Jianbin Wang#& Hai Qi#. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology, 23, 1564-1576, 2022.

 

2.Dan Liu*, Jiacong Yan*, Jiahui Sun*, Bo Liu ,Weiwei Ma ,Ye Li, Xingxing Shao , Hai Qi# , BCL6 controls contact-dependent help delivery during follicular T-B cell interactions. Immunity, 54: 2245-2255.e4, 2021.

 

3.Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature, 592:133-137, 2021.

4.Xu Zhang*, Bo Lei*, Yuan Yuan*, Li Zhang*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong#, Ji Hu# and Hai Qi#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.

5.Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.

6.Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, and Hai Qi#. PD-1 controls follicular T helper cell positioning and function. Immunity, 49:264-274, 2018.

 

7.Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017

8.Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017.

9.Ran He*, Shiyue Hou*, Cheng Liu*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu, Hai Qi#, Yuzhang Wu# and Lilin Ye#. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428, 2016.

 

10.Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015